Homologies between the major histocompatibility complex of man and cattle: Consequences for disease resistance and susceptibility
作者:
M. J. Giphart,
M. A. M. Groenen,
J. J. van der Poel,
期刊:
Veterinary Quarterly
(Taylor Available online 1990)
卷期:
Volume 12,
issue 4
页码: 202-211
ISSN:0165-2176
年代: 1990
DOI:10.1080/01652176.1990.9694267
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
The major histocompatibility complex (MHC) of mammals number of mostly duplicated contains a large genes. In the HLA system (the MHC of man), which is by far the best‐studied major histocompatibility system so far, roughly 20 genes have been defined and mapped. They code for three classes of proteins: HLA‐A, ‐B and ‐C (Class I), HLA‐DP, ‐DQ and ‐DR (Class II) and serum complement components C2, C4 and Bf (Class III). Furthermore, the region contains genes for 21‐hydroxylase (21‐OH) and tumor necrosis factor (TNF).
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