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Dopamine-dependent behavioural stimulation by non-peptide delta opioids BW373U86 and SNC 80: 1. Locomotion, rearing and stereotypies in intact rats

 

作者: L Spina,   R Longoni,   A Mulas,   K -J Chang,   G Di Chiara,  

 

期刊: Behavioural Pharmacology  (OVID Available online 1998)
卷期: Volume 9, issue 1  

页码: 1-8

 

ISSN:0955-8810

 

年代: 1998

 

出版商: OVID

 

关键词: behaviour;BW373U86;delta opioids;dopamine;locomotion;rat;SNC 80;stereotypies

 

数据来源: OVID

 

摘要:

The unconditioned behavioural effects of two non-peptide δ-opioid receptor agonists, BW 373U86 and SNC 80, were studied in the intact rat. BW 373U86 (0.1–2.5 mg/kg s.c.) and SNC 80 (2.5–10 mg/kg s.c.) dose-dependently elicited locomotion, rearing, stereotyped sniffing, licking and gnawing. These effects were abolished by pretreatment with the δ-opioid receptor antagonist naltrindole (5.0 mg/kg s.c.). In view of the phenomenological similarities between this syndrome and that elicited by dopamine-receptor agonists, the role played by dopamine receptors was investigated. The specific dopamine D1receptor antagonist SCH 23390 and the specific dopamine D2/D3receptor antagonist raclopride reduced or even abolished the behavioural stimulation induced by lower doses of BW 373U86 and SNC 80. When higher doses of BW 373U86 were used (2.5 mg/kg), however, raclopride, even at high cataleptic doses (6.0 mg/kg), only partly prevented the behavioural stimulation induced by the δ-opioid receptor agonist. The behavioural stimulation remaining after high doses of raclopride was abolished by the administration of SCH 23390. These results show that δ-opioid receptor stimulation elicits dopamine-dependent behavioural activation in the rat that depends on dopamine receptors, particularly of the D1subtype.

 

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