β‐Agonists in animal feed IV: Intercomparison study of a candidate reference confirmatory method
作者:
L. Leyssens,
J. P. Noben,
D. Courtheyn,
A. Boenke,
期刊:
Food Additives & Contaminants
(Taylor Available online 1996)
卷期:
Volume 13,
issue 8
页码: 883-895
ISSN:0265-203X
年代: 1996
DOI:10.1080/02652039609374477
出版商: Taylor & Francis Group
关键词: β2‐agonists;clenbuterol;salbutamol;residues;animal feedingstuffs;gas chromatography‐mass spectrometry;high‐pressure liquid‐chromatography
数据来源: Taylor
摘要:
The objective of this intercomparison study was to evaluate the qualitative aspects and the interlaboratory performance of the method selected to be recommended as the official Community reference confirmatory method for the analysis ofβ‐agonists in animal feed. This method contains three possible options, i.e. a narrow range method for clenbuterol‐type compounds based either on HPLC or on GCMS as the end‐determination step and a broad range GCMS method for clenbuterol‐type and salbutamol‐type‐β‐agonists. Three types of animal feed materials were provided: a series of blank materials and two series of materials contaminated with clenbuterol and salbutamol at a low and a high level, respectively. The results showed that the majority of the laboratories were able to identify blank, low and high level materials both for clenbuterol and salbutamol. For clenbuterol the narrow range GCMS method has been shown to be the most satisfactory. Although the participants had comments on the purity of the extracts obtained by means of the broad range method it was found appropriate as a multi‐residue method which is able to measure simultaneously clenbuterol‐type and salbutamol‐typeβ‐agonists. A statistical evaluation of the quantitative measurement was also performed.
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