Effect of Protein Deficiency on Cross-Linking and Maturation of Collagen
作者:
Upendra Prasad,
S.M. Bose,
期刊:
Annals of Nutrition and Metabolism
(Karger Available online 1974)
卷期:
Volume 16,
issue 3
页码: 172-180
ISSN:0250-6807
年代: 1974
DOI:10.1159/000175486
出版商: S. Karger AG
关键词: Protein deficiency;Gel reversibility;Lysyl oxidase;Collagen cross-linking;Allysine;Maturation process
数据来源: Karger
摘要:
To study the effect of protein deficiency on collagen cross-Unking in albino-rat skins and granulomas, two groups of weanling albino rats were raised for 3 weeks with normal and low protein diets by paired-feeding technique. The analysis of skins showed α1and α2-chain subunits of neutral salt-soluble collagen appreciably increased, β11- and β12-chains and the aldehyde content significantly decreased whereas the solubility of insoluble collagen in KCNS, urea or pronase increased greatly in protein-deficient animals compared to controls. The gel reversibility of neutral salt-soluble collagen increased in both skins and granulomas of protein-deficient animals compared to controls. The results indicate that in protein deficiency the cross-linking and maturation of collagen are impai
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