Interactions Among Combinations of Two and Three Protease Inhibitors Against Drug-Susceptible and Drug-Resistant HIV-1 Isolates
作者:
Cécile Tremblay,
Debra Merrill,
Ting-Chao Chou,
Martin Hirsch,
期刊:
JAIDS Journal of Acquired Immune Deficiency Syndromes
(OVID Available online 1999)
卷期:
Volume 22,
issue 5
页码: 430-430
ISSN:1525-4135
年代: 1999
出版商: OVID
关键词: Protease inhibitors;Combination therapy;Drug interactions
数据来源: OVID
摘要:
SummaryProtease inhibitors used in combination with reverse transcriptase inhibitors have demonstrated potent anti-HIV-1 activity in vitro as well as in vivo. We evaluated interactions among five protease inhibitors: indinavir (IDV), ritonavir (RTV), saquinavir (SQV), amprenavir (APV), and nelfinavir (NFV), when used in combinations of two and three drugs in vitro against several HIV-1 isolates, including those susceptible and resistant to various nucleoside and nonnucleoside reverse transcriptase inhibitors. Interactions ranged from synergy to slight antagonism depending on the viral isolates and the experimental conditions employed. Further clinical evaluation of protease inhibitor combinations is warranted.
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