HIV-Related Thrombocytopenia
作者:
BlockmansD.,
VermylenJ.,
期刊:
Acta Clinica Belgica
(Taylor Available online 1992)
卷期:
Volume 47,
issue 2
页码: 117-123
ISSN:1784-3286
年代: 1992
DOI:10.1080/17843286.1992.11718217
出版商: Taylor&Francis
数据来源: Taylor
摘要:
HIV-related chronic ITP is caused by an accelerated platelet destruction due to adsorption of circulating immune complexes and to specific anti-platelet antibodies, but perhaps also by a defective thrombo-poiesis resulting from invasion of the megakaryocytes by the retrovirus. Treatment is needed when platelet numbers drop beneath 20.10’/Lor when severe bleeding symptoms occur. Steroids, commercially available immunoglobulins for IV use, AZT and anti-Rh immunoglobulins can be administered, although relapses are frequent after withdrawal of the drugs. Recurrences after splenectomy are far less common, but the progression towards AIDS might be accelerated.
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