Recent Advances in the Management of Age-Related Macular Degeneration
作者:
ROBERT MITTRA,
LAWRENCE SINGERMAN,
期刊:
Optometry and Vision Science
(OVID Available online 2002)
卷期:
Volume 79,
issue 4
页码: 218-224
ISSN:1040-5488
年代: 2002
出版商: OVID
关键词: age-related macular degeneration;choroidal neovascularization;verteporfin therapy;Visudyne;photodynamic therapy
数据来源: OVID
摘要:
Choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) can cause rapid and severe central vision loss in many older people. Until recently, the only treatment proven beneficial was thermal laser photocoagulation, which was applicable to only a small subset of patients. Furthermore, the thermal laser damaged the retina overlying the CNV, which is especially problematic for lesions involving the foveal center. Photodynamic therapy is a new treatment consisting of intravenous infusion of a drug that is then activated by a low-energy laser, causing damage to CNV. Photodynamic therapy with verteporfin (Visudyne, Novartis AG) has been shown to reduce the risk of moderate and severe vision loss in patients with predominantly classic subfoveal CNV secondary to AMD. With the advent of verteporfin therapy, eye care providers will play an increasingly important role in managing patients with AMD, especially in the early detection and rapid referral of appropriate cases.
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