Autoantibody Associations with MHC Class II Antigens in Scleroderma and Autoimmune Vasculitis
作者:
ThomsonJ. B.,
HulseD.,
GalbraithI.,
McKayI. C.,
FieldM.,
期刊:
Autoimmunity
(Taylor Available online 1994)
卷期:
Volume 19,
issue 4
页码: 265-267
ISSN:0891-6934
年代: 1994
DOI:10.3109/08916939409071352
出版商: Taylor&Francis
关键词: MHC Class II antigens;Autoantibodies;Scleroderma;Vasculitis
数据来源: Taylor
摘要:
HLA-DR haplotypes in patients with scleroderma and vasculitis were compared with those in healthy controls from the Scottish population to investigate whether any associations exist between MHC antigens and development of specific autoantibodies.In patients with systemic vasculitis the presence of any antibodies against neutrophil cytoplasmic antigens (ANCA) was associated with an increased frequency of DR8 [p<0.004], and no patients expressed the DR5 antigen. However, no significant differences were observed when these patients were subdivided into those with anti-myeloperoxidase (MPO) antibodies or anti-proteinase-3 (PR3) antibodies.Scleroderma patients as a whole showed a lower frequency of DR7 than controls [5.1% cf 28% in control population, p<0.002], Following subdivision by autoantibody profile, patients with circulating anti-centromere antibody (ACA) showed an increased frequency of DR1 compared to the control population [p<0.001]. No scleroderma patient without ACA expressed this haplotype.Associations between MHC and some autoantibodies suggest that antigen presentation could lead to their production.
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