Systemic PCP treatment elevates brain extracellular 5‐HTa microdialysis study in awake rats
作者:
Peter Martin,
Maria Carlsson,
Stephan Hjorth,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 13
页码: 2985-2988
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: GABA;Microdialysis;NMDA receptor antagonist;Phencyclidine;Rat;Serotonin;Schizophrenia
数据来源: OVID
摘要:
THE NMDA receptor antagonist phencyclidine (PCP) has low micromolar affinity for the 5-HT reuptake site, but it is uncertain whether PCP blocks 5-HT reuptake when given systemically to rats in behaviourally stimulating doses. We here report for the first time that systemically administered PCP (5 mg/kg, s.c.) increases extracellular 5-HT levels in the rat medial prefrontal cortex (to 322%) and dorsal hippocampus (to 233%). Increases were found also when citalopram (μM) was included in the perfusion medium (to 184 and 180%, respectively). Extracellular 5-HIAA concentrations increased during both conditions, and extracellular GABA decreased in the dorsal hippocampus. It is concluded that systemic PCP treatment elevates extracellular 5-HT levels, probably through mechanisms other than a blockade of 5-HT reuptake
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