Comparative humoral responses to HIV‐1 p24gagand gp120envin subjects from East Africa and the UK
作者:
Pontiano Kaleebu,
Rachanee Cheingsong-Popov,
David Callow,
Elly Katabira,
Francis Mubiru,
Benon Biryahwaho,
Silvester Sempala,
Charles Gilks,
Richard Brindle,
Joab Were,
Jonathan Weber,
期刊:
AIDS
(OVID Available online 1991)
卷期:
Volume 5,
issue 8
页码: 1015-1020
ISSN:0269-9370
年代: 1991
出版商: OVID
关键词: Humoral responses;p24 Gag;gp120 Env;East Africa;UK
数据来源: OVID
摘要:
We compared 1616 sera from HIV-1-infected subjects and matched HIV-negative local controls in Uganda, Kenya and the UK. Sera were screened for specific antibody to HIV-1 p24 Gag and gp120 Env proteins and for p24 antigenaemia. In contrast to the UK, the majority of African HIV-1-infected subjects maintained detectable anti-p24 antibodies. However, lower reactivity of anti-p24 was observed in African AIDS patients, compared with those with asymptomatic HIV-1 infection. This reduction in anti-p24 reactivity with more advanced clinical stage was less marked in African HIV-1 infection than in the UK. Correspondingly, p24 antigenaemia was more common in patients with AIDS from the UK than in African patients (65 versus 4%). Reductions in anti-gp120 reactivity were observed in African AIDS patients, compared with the asymptomatic group. However, median reactivity of anti-gp120 in UK patients remained unchanged in both asymptomatic and AIDS subjects. The differences in humoral response to p24 and gp120 between Africa and the UK are semi-quantitative rather than qualitative and could be explained by initial higher antibody response to HIV-1 in African subjects.
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