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Syntheses of no‐carrier‐added (NCA) [18F]fluoroalkyl halides and their application in the syntheses of [18F]fluoroalkyl derivatives of neurotransmitter receptor active compounds

 

作者: C.‐Y. Shiue,   L.‐Q. Bai,   R.‐R. Teng,   A. P. Wolf,  

 

期刊: Journal of Labelled Compounds and Radiopharmaceuticals  （WILEY Available online 1987）
卷期: Volume 24, issue 1  

页码: 55-64

 

ISSN:0362-4803

 

年代: 1987

 

DOI:10.1002/jlcr.2580240108

 

出版商: John Wiley&Sons, Ltd.

 

关键词: NCA [18F]Fluoroalkyl halides;N‐(2‐[18F]fluoroethyl)spiroperidol;N‐(3‐[18F]fluoropropyl)spiroperidol;(±)‐N‐(3‐[18F]fluoropropyl)‐normetazocine;N‐(3‐[18F]fluoropropyl)lorazepam;nucleophilic aliphatic substitution reaction;fluorine‐18

 

数据来源: WILEY

 

摘要:

AbstractNucleophilic aliphatic substitution of alkyl halides,1, [(CH2)nX2(n=2, 3; X=Br,I)], with NCA K[18F]/Kryptofix 2.2.2 in CH3CN gave the corresponding NCA [18F]fluoroalkyl halides2in 30–40% yields. The factors which influence the yield of2were compared.N‐Alkylation of several neurotransmitter receptor active amides and amines with this reagent gave the corresponding NCAN‐[18F]fluoroalkyl derivatives (3–6) in 20–

 

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