Non‐drug‐related residues in tracer studies
作者:
Charles Rosenblum,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1977)
卷期:
Volume 2,
issue 4
页码: 803-814
ISSN:0098-4108
年代: 1977
DOI:10.1080/15287397709529480
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Factors involved in residue studies with radioactive tracers are discussed. Three types of metabolic management of14C‐labeled compounds are described. Intact incorporation into protein of chick muscle is demonstrated with L‐O‐ethyl‐[14C/threonine. Retention of unchanged and quantitatively recoverable parent compound occurred with [14C] thiabendazole sprayed on oranges. The latter drug fed to animals was retained in tissue partly intact, but mostly metabolized to recognizable detoxification products, and ultimately to endogenous tissue components. The latter type of residue was termed a “nonmetabolite” residue. The extreme case of extensive metabolism to products structurally unrelated to the parent compound was illustrated with [14C] ronidazole administered to turkeys.
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