RopiniroleFor the Treatment of Restless Legs Syndrome
作者:
Susan M Cheer,
Lynne M Bang,
Gillian M Keating,
期刊:
CNS Drugs
(ADIS Available online 2004)
卷期:
Volume 18,
issue 11
页码: 747-754
ISSN:1172-7047
年代: 2004
出版商: ADIS
关键词: Dopamine receptor agonists, general;Ropinirole, general;Restless legs syndrome, treatment;Adis Drug Profiles
数据来源: ADIS
摘要:
▴ Ropinirole is a non-ergoline dopamine agonist that exhibits a high affinity for D2and D3receptors but little or no affinity for D1-like and non-dopaminergic receptors.▴ Symptoms of restless legs syndrome (RLS) [measured using the International Restless Legs scale and Clinical Global Impression-Global Improvement Scale scores] significantly improved with ropinirole compared with placebo in large, randomised, double-blind trials.▴ Ropinirole reduced periodic leg movements and improved sleep efficiency relative to baseline and placebo in several trials (two of which were randomised, double-blind and relatively large) in patients with RLS.▴ Ropinirole was generally well tolerated in patients with RLS; adverse events were generally mild to moderate in nature and consistent with those expected of dopamine agonists. Few patients receiving ropinirole withdrew from therapy because of adverse events, the most predominant of which were nausea and headache.
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