Effects of Carbamazepine and Sodium Valproate on 5-HT-Induced Calcium Increase in Individual C6 Rat Glioma Cells
作者:
Takayuki Yamaji,
Ariyuki Kagaya,
Yosuke Uchitomi,
Norio Yokata,
Shigeto Yamawaki,
期刊:
Neuropsychobiology
(Karger Available online 1996)
卷期:
Volume 34,
issue 1
页码: 22-25
ISSN:0302-282X
年代: 1996
DOI:10.1159/000119286
出版商: S. Karger AG
关键词: Carbamazepine;Sodium valproate;Affective disorders;Intracellular Ca2+mobilization;Serotonin;Rat C6BU-1 glioma cells
数据来源: Karger
摘要:
The effects of drugs for affective disorders on the sustained phase of serotonin (5-HT)-induced calcium (Ca2+) response were investigated in single C6BU-1 glioma cells with digital imaging microscopy. The sustained phase was significantly attenuated by 32 µM carbamazepine and 320 µM sodium valproate as well as 100 nM clomipramine and verapamil, whose effects we evaluated in our previous report. The present findings demonstrate that drugs for affective disorders, in their therapeutic concentrations, have common action of inhibiting Ca2+ influx, and suggest that the Ca2+ antagonistic effect may play an important role in the mechanism of the action sites of the drugs for affective disorder
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