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A Pharmacophore Hypothesis for Antidepressant Activity: Accomodation of Viloxazine

 

作者: George R. Brown,  

 

期刊: Quantitative Structure‐Activity Relationships  （WILEY Available online 1989）
卷期: Volume 8, issue 1  

页码: 49-49

 

ISSN:0931-8771

 

年代: 1989

 

DOI:10.1002/qsar.19890080107

 

出版商: WILEY‐VCH Verlag

 

关键词: Tricyclic antidepressant;viloxazine;pharmacophore;imipramine;amitriptyline

 

数据来源: WILEY

 

摘要:

AbstractIn a previous study of the conformation‐activity relationships of antidepressant drugs a pharmacophore hypothesis was developed. This report shows that an incorrect structure of viloxazine was used to validate the hypothesis and comments on the relevance of the fit of the correct structure of viloxazine to the pharmacophor

 

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