Prevalence of HIV‐1 DNA and p24 Antigen in Breast Milk and Correlation with Maternal Factors
作者:
Andrea Ruff,
Jacqueline Coberly,
Neal Halsey,
Reginald Boulos,
Julio Desormeaux,
Ann Burnley,
Delourdes Joseph,
Maureen McBrien,
Thomas Quinn,
Phyllis Losikoff,
Katherine O'Brien,
Marie Louis,
Homayoon Farzadegan,
期刊:
Journal of Acquired Immune Deficiency Syndromes
(OVID Available online 1994)
卷期:
Volume 7,
issue 1
页码: 68-73
ISSN:0894-9255
年代: 1994
出版商: OVID
关键词: Maternal-infant HIV-1 transmission;Breast milk;Breast-feeding;HIV-1 PCR;HIV-1 p24 antigen.
数据来源: OVID
摘要:
SummaryBreast milk specimens from human immunodeficiency virus type 1 (HIV-1)-seropositive and HIV-1-seronegative women were examined for the presence of HIV-1 p24 antigen by the antigen capture method and for viral DNA using the polymerase chain reaction. HIV-1 DNA was present in 70% of milk specimens collected from 47 HIV-seropositive women 0–4 days after delivery and in ∼50% of specimens collected 6 and 12 months postpartum. p24 antigen, present in 24% of milk specimens collected from 37 seropositive women within the first 4 days postpartum, was not detected in any of the subsequent specimens. The presence of HIV-1 DNA or p24 antigen in milk was not significantly associated with maternal CD4 lymphocyte count, β2-microglobulin level, or fulfillment of the AIDS clinical case definition. Although the correlation of either HIV-1 proviral DNA or p24 antigen with the presence of infectious virus is not known, these data indicate the need for additional studies examining the role of breastfeeding in maternal-infant transmission of HIV-1.
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