Morphine Pharmacokinetics During Anesthesia and Surgery in Patients with Burns
作者:
William,
Furman Andrew,
Munster Edward,
期刊:
Journal of Burn Care & Rehabilitation
(OVID Available online 1990)
卷期:
Volume 11,
issue 5
页码: 391-394
ISSN:0273-8481
年代: 1990
出版商: OVID
数据来源: OVID
摘要:
The plasma clearance, plasma half-life, and apparent volume of distribution of morphine during anesthesia and surgery were determined in seven patients with burns and compared with seven age-matched control subjects. The burn group had a significantly lower clearance, longer terminal half-life, and smaller volume of distribution than the control group. The clearance was 12 ± 2 ml/min/kg, the half-life was 123 ± 24 minutes, and the volume of distribution was 2.2 ± 0.4 L/kg for the subjects with burns compared with 25 ± 3 ml/min/kg, 89 ± 18 minutes, and 3.2 ± 0.8 L/kg for the control subjects (p< 0.001, < 0.02, and < 0.02, respectively). These data contrast with the theory that patients with burns have a tolerance to narcotics and suggest the need for further study of the pharmacologic effects of burn injury and surgery.
点击下载:
PDF
(296KB)
返 回