Angiographic abnormalities of experimental autoimmune uveoretinitis
作者:
HoweLucy J.,
StanfordMiles R.,
WhistonRoy,
DewhirstRichard,
MarshallJohn,
期刊:
Current Eye Research
(Taylor Available online 1996)
卷期:
Volume 15,
issue 12
页码: 1149-1155
ISSN:0271-3683
年代: 1996
DOI:10.3109/02713689608995149
出版商: Taylor&Francis
关键词: choroid;experimental autoimmune uveoretinitis;fluorescein angiography;indocyanine green angiography
数据来源: Taylor
摘要:
Purpose. Experimental autoimmune uveoretinitis (EAU) is an invaluable animal model for studying inflammatory eye disease in humans. Indocyanine green (ICG) is a fluorescent dye that can be used to image both retinal and choroidal vessels. This study was performed to examine the retinal and choroidal vascular abnormalities of a rat model of EAU using ICG and fluo-rescein as the contrast media and to assess the suitability of this model for studying ICG angiographic abnormalities in inflammatory eye disease in humans.Methods. Twenty-six male black-hooded Lister rats were inoculated with bovine retinal S-antigen plus adjuvant with or withoutBordetella pertussisantigen. Fluorescein and ICG angio-grams were performed at different stages of clinical disease with a scanning laser ophthalmoscope.Results. EAU was a more severe and primarily choroidal disease in rats givenBordetella pertussis, but no animals showed evidence of dye leakage from large choroidal vessels. There was frank leakage of indocyanine green from retinal vessels. Leakage of both fluorescein and ICG from retinal vessels largely correlated with disease activity. Retinal pigment epithelial lesions either corresponded to areas of hypofluorescence on the ICG angiogram alone or were represented by areas of ICG hyperfluo-rescence that had overlying areas of fluorescein leakage from retinal capillaries.Conclusions. This study has demonstrated the vascular abnormalities of this model of EAU using ICG and fluorescein as the contrast media. The suitability of this model for studying ICG angiographic abnormalities in inflammatory eye disease in humans is encouraging.
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