Pertussis Toxin and 4‐Amino pyridine Differentially Affect the Hypnotic–Anesthetic Action of Dexmedetomidine and Pentobarbital
作者:
Van Doze,
Bing-Xue Chen,
Julie Tinklenberg,
Ira Segal,
Mervyn Maze,
期刊:
Anesthesiology
(OVID Available online 1990)
卷期:
Volume 73,
issue 2
页码: 304-307
ISSN:0003-3022
年代: 1990
出版商: OVID
关键词: Anesthetics, hypnotics: pentobarbital.;G-proteins: pertussis toxin.;Potassium channels: 4-aminopyridine.;Receptors, adrenergic: α2.;Sympathetic nervous system, α2-adrenoceptor agonist: dexmedetomidine.
数据来源: OVID
摘要:
Dexmedetomidine, a highly selective and potent agonist at alpha-2 adrenoceptors, produces a hypnotic-anesthetic action in rats. The mechanism for this response may involve an inhibitory G-protein and increased conductance through a potassium channel. To investigate this, the effects of pertussis toxin, a specific inactivator of inhibitory G-proteins, and 4-aminopyridine, a blocker of potassium channels, on the hypnotic-anesthetic response to dexmedetomidine were studied in rats. Pertussis toxin and 4-aminopyridine both decreased the hypnotic-anesthetic action of dexmedetomidine in a dose-dependent fashion. To preclude the possibility that pertussis toxin and 4-aminopyridine attenuated the hypnotic-anesthetic action of dexmedetomidineviaindirect central nervous system excitation, the effects of pertussis toxin and 4-aminopyridine on the hypnotic-anesthetic action of pentobarbital also were assessed. Pentobarbital-induced hypnosis was not attenuated by either treatment. These results suggest that the receptor-effector mechanism for the hypnotic-anesthetic action of dexmedetomidine involves an inhibitory G-protein and increased conductance through a potassium channel.
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