Ultrastructural Alteration of the Alveolar Epithelium after Exposure to Organic Solvents
作者:
N. Schnoy,
R. Schmidt,
H. Altenkirch,
H.M. Wagner,
期刊:
Respiration
(Karger Available online 1982)
卷期:
Volume 43,
issue 3
页码: 221-231
ISSN:0025-7931
年代: 1982
DOI:10.1159/000194487
出版商: S. Karger AG
关键词: Lung;Ultrastructure;Solvents;Toxicity
数据来源: Karger
摘要:
Adult rats were exposed to the solvents n-hexane and methylethylketone (MEK) in different concentrations. Lung tissue was examined systematically after various periods by electron microscopy. The direct toxic effect to pneumocytes could be demonstrated as definite regressive alterations, such as fatty degeneration and changements of lamellar bodies of type II pneumocytes as well as increased detachment of cells. Besides these findings, after chronic inhalation of solvents conspicuous aggregation of lamellar discharge material of type II pneumocytes can be seen, and probably, as a result of an irritated fat metabolism, large lysosome-like bodies with densely packed lipid material appear in type I pneumocytes. The most distinguished changements could be demonstrated after exposure to a mixture of n-hexane and MEK, while they were less obvious after n-hexane alone. The observation suggests a profound enzymatic irritation of metabolism.
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