The nature of allorecognition
作者:
Alan Krensky,
Carol Clayberger,
期刊:
Current Opinion in Nephrology and Hypertension
(OVID Available online 1993)
卷期:
Volume 2,
issue 6
页码: 898-903
ISSN:1062-4821
年代: 1993
出版商: OVID
数据来源: OVID
摘要:
Understanding the nature of allorecognition is fundamental to the design of antigen-specific therapies for transplantation. As recently as 10 years ago it was generally believed that recognition of major histocompatibility complex (MHC) molecules by T lymphocytes was direct and represented the “simplest” kind of T-lymphocyte interaction. It is now clear that the nature of allorecognition is complex, involving a variety of different forms of MHC antigens with or without peptides contained in their antigen-binding groove. In addition, there is renewed interest in alternative forms of allorecognition, including so-calledindirect allorecognition, in which donor alloantigens are recognized as peptides in the context of recipient self. Lastly, it appears that cells other than T lymphocytes, eg, natural killer cells, are capable of antigen-specific recognition and may be responsible for heretofore underappreciated mechanisms of transplant rejection.
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