Carboxyhemoglobin Levels in Patients with Sickle-Cell Anemia: Relationship to Hemolytic and Vasoocclusive Severity
作者:
David Sears,
Mark Udden,
Linda Thomas,
期刊:
The American Journal of the Medical Sciences
(OVID Available online 2001)
卷期:
Volume 322,
issue 6
页码: 345-348
ISSN:0002-9629
年代: 2001
出版商: OVID
关键词: Carboxyhemoglobin;Sickle-cell anemia
数据来源: OVID
摘要:
Background:When carbon monoxide binds to hemoglobin, it increases the affinity of hemoglobin for oxygen and shifts the oxygen dissociation curve to the left. The resulting decrease in sickling tendency could have clinical benefit, and carbon monoxide has been suggested as a treatment for sickle-cell disease. Furthermore, in sickle-cell disease, as in other hemolytic diseases, endogenous carbon monoxide production is increased because of increased heme catabolism.Methods:In the present study, we measured carboxyhemoglobin levels in sickle-cell patients and compared them with estimates of the hemolytic and the vaso-occlusive severity of the disease.Results:Significant correlation was found between carboxyhemoglobin (HbCO) levels and hematocrit, reticulocyte count, unconjugated bilirubin level, and percentage of irreversibly sickled cells. However, there was no significant correlation between carboxyhemoglobin levels and measures of the vaso-occlusive severity of the disease.Conclusions:The correlations between HbCO levels and measures of hemolytic severity are best explained by the known relationship between hemoglobin catabolism and CO production. The lack of correlation with vaso-occlusive severity may be due to the complex changes involved and the difficulty of quantifying vaso-occlusive severity.
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