Effects of cadmium inhalation on mitochondrial enzymes in rat tissues
作者:
P. V. V. Prasada Rao,
D. E. Gardner,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1986)
卷期:
Volume 17,
issue 2-3
页码: 191-199
ISSN:0098-4108
年代: 1986
DOI:10.1080/15287398609530815
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Pulmonary and extrapulmonary effects from a 2‐h inhalation exposure to cadmium (850 μg Cd/m3) were studied in male rats. The effect of this chemical on mitochondrial enzyme activity in the lung, liver, kidney, and testis were investigated immediately after exposure and at 48, 144, and 336 h postexposure. In all tissues studied, mitochondrial citrate synthase activity was significantly increased immediately after the cessation of the exposure. This activity level began to decrease at 48 h postexposure. Succinic dehydrogenase activity was significantly decreased in the lungs and kidney at all periods tested, but increased activity was seen in the liver and testis. Cytochrome c oxidase activity in lungs and testis mictochondria was inhibited at all time periods studied. In the liver and kidney this activity was significantly increased immediately after the exposure ceased, and then a significant reduction began to appear at 48 h postexposure. This study demonstrates that inhaled cadmium, after deposition in the lungs, may alter various enzyme activities in other organs.
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