Estrogen Induces Synaptic Plasticity in Adult Primate Neurons
作者:
Frederick Naftolin,
Csaba Leranth,
Julio Perez,
Luis Miguel Garcia-Segura,
期刊:
Neuroendocrinology
(Karger Available online 1993)
卷期:
Volume 57,
issue 5
页码: 935-939
ISSN:0028-3835
年代: 1993
DOI:10.1159/000126456
出版商: S. Karger AG
关键词: Estrogen;Synapse;Neural plasticity;Glia;Astrocytes;Monkeys;Thalamus;Hypothalamus;Infundibular nucleus
数据来源: Karger
摘要:
The number of axosomatic synapses, the length of the synaptic plates and the perimeter of the post synaptic neuronal perikarya were assessed on thin sections from the infundibular hypothalamic nucleus and from the ventrobasal thalamus of 3 adult ovariectomized African green monkeys that were treated with estradiol valerate and of 3 control animals that were injected with vehicle. Estradiol valerate treatment resulted in a 39% decrease in the number of axosomatic synapses in the infundibular hypothalamic nucleus. The length of the synaptic plates and the perimeter of the postsynaptic cells were not affected by the hormonal treatment. The decrease in the number of axosomatic synaptic inputs in the infundibular hypothalamic nucleus was accompanied by a significant increase in the glial ensheathing of neuronal somas. No effect of the hormonal treatment was detected in the ventrobasal thalamus. The results indicate that estrogen may induce glial and synaptic plasticity in the hypothalamus of adult primates.
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