Pharmacokinetics of lidocaine and its active metabolites in dogs
作者:
J. R. WILCKE,
L. E. DAVIS,
C. A. NEFF‐DAVIS,
G. D. KORITZ,
期刊:
Journal of Veterinary Pharmacology and Therapeutics
(WILEY Available online 1983)
卷期:
Volume 6,
issue 1
页码: 49-57
ISSN:0140-7783
年代: 1983
DOI:10.1111/j.1365-2885.1983.tb00454.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
The pharmacokinetics of lidocaine in dogs were investigated following the intravenous and intramuscular administration of single doses of lidocaine hydrochloride. The mean elimination rate constant and the mean specific clearance determined for the intravenous portion of the study were 0.786 h‐1and 2.40 1/kg/h, respectively. Following intramuscular administration the mean absorption rate constant was 7.74 h‐1. Absorption was nearly complete as the percentage of an intramuscular dose absorbed averaged 91.9%. Concentrations of two N‐deethylated metabolites, determined following the administration of lidocaine suggest that monoethylglycinexylidide is eliminated rapidly while glycinexylidide is more slowly eliminated. The relative contribution of these metabolites to the therapeutic and toxic effects of lidocaine and the potential for glycinexylidide accumulation during lidocaine administration remain to be investi
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