Sensing phosphate across the kingdoms
作者:
Justin Silver,
Michal Dranitzki-Elhalel,
期刊:
Current Opinion in Nephrology and Hypertension
(OVID Available online 2003)
卷期:
Volume 12,
issue 4
页码: 357-361
ISSN:1062-4821
年代: 2003
出版商: OVID
关键词: NaPi;parathyroid hormone;phosphate
数据来源: OVID
摘要:
Purpose of reviewThe present review summarizes recent findings that may help in understanding how the cell senses changes in serum phosphate.Recent findingsThe sensing of phosphate determines the organism's response to change in supply of this essential nutrient. Phosphate depletion or surfeit results in homeostatic responses that involve changes in transcription, transcript stability, transporter recruitment or breakdown, and cell replication. These responses are shared across the biological kingdoms, and lessons from unicellular organisms may be relevant to multicellular mammals. An understanding of nutrient sensing in general may help in determining how the cell senses changes in phosphate concentration.SummaryResearch has yielded important advances in unravelling phosphate sensing and the response to nutrient phosphate supply. However, the actual sensing event for phosphate and most other nutrients must still be defined. Lessons may be learned from those examples in which the sensing event is known, and these are summarized here.
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