Fibrillin delineates the primary axis of the early avian embryo
作者:
Betty C. Gallagher,
Lynn Y. Sakai,
Charles D. Little,
期刊:
Developmental Dynamics
(WILEY Available online 1993)
卷期:
Volume 196,
issue 1
页码: 70-78
ISSN:1058-8388
年代: 1993
DOI:10.1002/aja.1001960109
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: Fibrillin;Avian embryos;Marfan syndrome;Primary axis;Dorsal mesoderm;Hensen's node;Primitive streak
数据来源: WILEY
摘要:
AbstractChicken embryos were immunolabeled with antibodies to fibrillin, an extracelular matrix molecule implicated in the Marfan syndrome. The pattern of labeling, established using both whole‐mounted and sectioned embryos, showed a striking localization at the primary axis of the early embryo, including Hensen's node. After stage 8, the labeling of Hensen's node diminished while other structures in the embryo exhibited increased immunolabeling. These structures include the region of the presumptive dorsal aorta, the ventral surface of the notochord, and the mesocardium. Injections of the antibody between the vitelline membrane and the blastoderm in vivo failed to perturb the development of embryos, thus precluding any conclusions regarding the function of fibrillin. © 1993 wiley‐Liss,
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