Endotoxin protection against oxygen toxicity and its reversal by acetylsalicylic acid
作者:
JAN KLEIN,
ADRIANUS TROUWBORST,
PATRICK SALT,
期刊:
Critical Care Medicine
(OVID Available online 1986)
卷期:
Volume 14,
issue 1
页码: 32-33
ISSN:0090-3493
年代: 1986
出版商: OVID
数据来源: OVID
摘要:
This study investigated the involvement of substances derived from arachidonic acid in the mechanism of endotoxin's protective action against pulmonary oxygen toxicity, Eighty-three percent of rats treated with a small dose of endotoxin (1 mg/kg) survived exposure to over 95% oxygen for 7 days. In contrast, all control rats exposed to the same oxygen concentration died within 3 days. When the endotoxin-treated rats were also treated with the soluble lysine salt of acetylsalicylic acid (100 mg/kg), 7-day survival decreased to 25%. This suggests that prostaglandin metabolism may play an important role in the protective action of endotoxin during hyperoxia.
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