Ranitidine and prevention of pulmonary aspiration syndrome
作者:
U. AROMAA,
T. V. KALIMA,
期刊:
Acta Anaesthesiologica Scandinavica
(WILEY Available online 1986)
卷期:
Volume 30,
issue 1
页码: 10-12
ISSN:0001-5172
年代: 1986
DOI:10.1111/j.1399-6576.1986.tb02357.x
出版商: Blackwell Publishing Ltd
关键词: Acid aspiration syndrome;anaesthesia premedication;Mendelson's syndrome;ranitidine
数据来源: WILEY
摘要:
Thirty‐seven patients undergoing elective abdominal surgery (excluding gastric operations) received either ranitidine 300 mg or placebo orally at 10 p. m. in the evening preceding surgery in a double‐blind randomised study. The mean time interval between this oral premedication and induction of anaesthesia was 12 h. When compared to placebo, ranitidine decreased significantly (P<0.05) the amount of gastric juice, and none of the ranitidine‐treated patients had an increased risk of acid pulmonary aspiration (pH below 2.5 and volume over 25 ml), while four patients in the control group had an increased risk (21%). The mean ranitidine blood level was 237 ng/ml at the time of induction of anaesthesia. It is concluded that in elective abdominal surgery ranitidine included in the premedication is likely to decrease the risk for acid pulmonary aspir
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