Acetylene oxidation in a jet-stirred reactor has been investigated at high temperature (800-1100 K) in the pressure range 1 to l0atm. Molecular species concentration profiles of H2, CO, CO2, CH4, C2H2, C2H4, C2H6were obtained by probe sampling and GC analysis. Acetylene oxidation was modeled using a comprehensive kinetic reaction mechanism including the most recent findings concerning the kinetics of the reactions involved in the oxidation of C1,—C6hydrocarbons. The proposed mechanism is able to reproduce experimental data obtained in our high-pressure jet-stirred reactor, ignition delay times measured in shock tube, atmospheric pressure C2H2/Air flame speeds, and C2H2/O2/Ar premixed flame structures obtained at low pressure on flat flame burners. The mechanism has also been used successfully to represent the kinetics of the oxidation of CH4, C2H4, C2H6, C3H6, C3H3, mixtures of CH4with C2H6and/or C3,H8in the same conditions