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Linkage Analysis in Nuclear Families. 2: Relationship between Affected Sib-Pair Tests and Lod Score Analysis

 

作者: M. Knapp,   S.A. Seuchter,   M.P. Baur,  

 

期刊: Human Heredity  (Karger Available online 1994)
卷期: Volume 44, issue 1  

页码: 44-51

 

ISSN:0001-5652

 

年代: 1994

 

DOI:10.1159/000154188

 

出版商: S. Karger AG

 

关键词: Affected sib-pair method;Mean test;Proportion test;Lod score analysis;Equivalent tests

 

数据来源: Karger

 

摘要:

It is believed that the main advantage of affected sib-pair tests is that their application requires no information about the underlying genetic mechanism of the disease. However, here it is proved that the mean test, which can be considered the most prominent of the affected sib-pair tests, is equivalent to lod score analysis for an assumed recessive mode of inheritance, irrespective of the true mode of the disease. Further relationships of certain sib-pair tests and lod score analysis under specific assumed genetic modes are investigated.

 

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