Randomized Double-Blind Multicenter Study Comparing Acitretin-PUVA, Etretinate-PUVA and Placebo-PUVA in the Treatment of Severe Psoriasis
作者:
J.-H. Saurat,
J.-M. Geiger,
P. Amblard,
J.-C. Beani,
A. Boulanger,
A. Claudy,
E. Frenk,
J.-J. Guilhou,
E. Grosshans,
Y. Mérot,
J. Meynadier,
B. Tapernoux,
期刊:
Dermatology
(Karger Available online 1988)
卷期:
Volume 177,
issue 4
页码: 218-224
ISSN:1018-8665
年代: 1988
DOI:10.1159/000248567
出版商: S. Karger AG
关键词: Acitretin;Etretinate;Re-PUVA;Psoriasis
数据来源: Karger
摘要:
A randomized double-blind study was designed with 65 patients in order to clarify two points: (1) does addition of a retinoid to psoralen-ultra violet A photochemotherapy (PUVA) of severe psoriasis decrease the UVA energy required to achieve remission, and (2) is there a difference between two retinoids, i.e. etretinate and acitretin. Acitretin-PUVA treatment was significantly superior to placebo-PUVA with respect to several items (decrease in lesional scores after 6 weeks of therapy, number of PUVA exposures, and total dose of UVA until remission). There were also differences between the etretinate-PUVA and placebo-PUVA groups, but only the decrease in lesional scores reached statistical significance.
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