Hypercalcemia is a fairly common complication of certain types of malignancy. The manifestations of cancer-induced hypercalcemia may be unpleasant for the patient and are potentially life-threatening. Prompt diagnosis of this complication, followed by effective treatment, usually can reverse the condition. This article provides current information regarding incidence, pathophysiology, manifestations, treatment, and suggestions for possible prevention of symptoms of cancer-induced hypercalcemia. Nurses involved in the care of cancer patients need to be able to assess their patients for manifestations of hypercalcemia. Nurses also have a responsibility to make patients at risk to develop cancer-induced hypercalcemia aware of this complication and of the measures they may take to possibly prevent its occurrence.