Growth cone‐target interactions in the frog retinotectal pathway
作者:
T.A. Reh,
M. Constantine‐Paton,
期刊:
Journal of Neuroscience Research
(WILEY Available online 1985)
卷期:
Volume 13,
issue 1‐2
页码: 89-100
ISSN:0360-4012
年代: 1985
DOI:10.1002/jnr.490130107
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: Rana pipiens;retinotectal projection;growth cones
数据来源: WILEY
摘要:
AbstractThe growth cones of retinal ganglion cell axons were studied in the optic tract and tectum with hoseradish peroxidase (HRP) histochemistry and electron microscopy. The ganglion cell growth cones has many morphological features similar to those described in vitro and in other in vivo systems. However, we found that some processes formed highly differentiated terminal arborizations, while retaining growth cones on many of their branches. In addition, ultrastructural examination of the tectal neuropil revealed that many ganglion cell axonal processes had characteristics of both growth cones and presynaptic endings. These findings are discussed in the context of the hypothesis of shifting connections and the evidence that retinotectal map formation involves several mechanisms, including a process that depends on the action potential activity in the optic fibers.
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