首页   按分类浏览 期刊浏览 卷期浏览 Synthesis of steroids and related compounds
Synthesis of steroids and related compounds

 

作者: I.N.Nazarov,   S.I.Zavyalov,  

 

期刊: Bulletin of the Academy of Sciences of the USSR, Division of chemical science  (Springer Available online 2005)
卷期: Volume 6, issue 2  

页码: 219-223

 

ISSN:0568-5230

 

年代: 2005

 

DOI:10.1007/BF01170556

 

出版商: Springer_US-Boston

 

数据来源: Springer

 

摘要:

1.By the condensation of 1,3-cyclohexanedione (I) with 3-buten-2-one, a mixture of the 3-oxobutyl derivatives (II) and (III) was formed. By the action of diazomethane on the ketone (II), the pure methyl ether of the enol form of 2-(3-oxobutyl)-1,3-cyclohexanedione was obtained, and treatment of this with potassium tert-butoxide gave the bicyclic methoxy ketone(XI ).2.Hydrolysis of the methoxy ketone (XI) with dilute hydrochloric acid gave 3,4,7,8-tetrahydro-1,6(2H, 5H)-naphthalenedione (IX) In high, yield.3.With diazomethane 3,4,7,8-tetrahydro- 1,6(2H,5H)-naphthalenedione (IX) gave the bicyclic methoxy ketone (VI), which was converted by dehydrogenation with sulfur into the known 3,4-dihydro-6-methoxy-1(2H)-naphthalenone (VII).4.By reaction of p-methoxyphenylmagnesium and 4-methoxyw-o-tolylmagnesium bromides with the methoxyketone (XI). and subsequent hydrolysis, isomerization, and dehydration of the reaction products, the dienic ketones (XIII) and (XIV) were obtained. These ketones are of interest as model steroid analogs not containing ring B.

 

点击下载:  PDF (345KB)



返 回