HLA Typing and Affective Disorders: a Study in the Italian Population
作者:
E. Smeraldi,
F. Negri,
A.M. Melica,
R. Scorza-Smeraldi,
G. Fabio,
P. Bonara,
L. Bellodi,
E. Sacchetti,
M.G. Sabbadini-Villa,
C.L. Cazzullo,
C. Zanussi,
期刊:
Neuropsychobiology
(Karger Available online 1978)
卷期:
Volume 4,
issue 6
页码: 344-352
ISSN:0302-282X
年代: 1978
DOI:10.1159/000117650
出版商: S. Karger AG
关键词: HLA antigens;Affective disorders
数据来源: Karger
摘要:
HLA phenotype distribution was investigated in 91 affective patients. Significant increases over those of the control population were found in HLA-A 29 and in Bw 22 frequencies, while A 10 and A 30 were decreased. No significant difference was shown between the two clinical subgroups (41 unipolar patients and 50 bipolar ones). On comparing our data with those from other authors, Bw 16 was significantly increased. However, a high degree of heterogeneity was also shown for this antigen. Of some interest is the finding that relapsed and non-relapsed patients during long-term lithium therapy display diverging HLA phenotype distributions, with B 5 increased among the non-relapsed subjects.
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