Approaches to the development of novel inhibitors of hepatitis C virus replication
作者:
B. E. Clarke,
期刊:
Journal of Viral Hepatitis
(WILEY Available online 1995)
卷期:
Volume 2,
issue 1
页码: 1-8
ISSN:1352-0504
年代: 1995
DOI:10.1111/j.1365-2893.1995.tb00066.x
出版商: Blackwell Publishing Ltd
关键词: chemotherapy;hepatitis C virus.
数据来源: WILEY
摘要:
SUMMARY.Chronic infection with the hepatitis C virus is a major health problem. Conventional therapy, with interferon‐α is effective in only a minority of patients. The failure of current treatments has led to a major initiative to identify new antiviral agents. In the absence of a tissue culture model for hepatitis C infection the phwaceutical industry has been obliged to investigate the basic biology of hepatitis C viral replication. Such studies have identified novel translational regulatory elements and new proteolytic enzymes which may serve as targets for new antiviral dru
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