Subchronic inhalation toxicity of methanol
作者:
L. S. Andrews,
JohnJ. Clary,
J. B. Terrill,
HenryF. Bolte,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1987)
卷期:
Volume 20,
issue 1-2
页码: 117-124
ISSN:0098-4108
年代: 1987
DOI:10.1080/15287398709530965
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
The subchronic inhalation toxicity of methanol was evaluated in rats and monkeys. Animals were exposed to 0, 500, 2000, and 5000 ppm methanol vapor for 6 h/d, 5 d/w, for 4 wk. The only treatment‐ and dose‐related effect noted was that of mucoid nasal discharge in rats, which was considered reflective of upper respiratory tract irritation. No consistent treatment‐related effects were found for organ or body weights or for histopathologic or ophthalmoscopic examinations. Overall, these findings support the use of the present American Council of Governmental Industrial Hygienists threshold limit value (TLV) of 200 ppm and short‐term exposure limit (STEL) of 250 ppm for exposure to methanol vapor.
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