This article focuses on several subtopics of intestinal circulatory physiology and pathophysiology. More than 200 recent publications were examined before a small group of papers were selected for this survey, which epitomizes the problem confronted by a reviewer searching an active field. The subtopics into which these papers were divided include 1) regulatory events, such as aging, autoregulation, adenosine, intraluminal lipid, and sensory nerves; 2) nitric oxide-related investigations, including its role in portal vein stenosis, the serum albumin nitric oxide reservoir, and a novel biosensor for it; 3) ischemia-reperfusion injury-related topics, namely the effects of intraluminal pancreatic proteases, the important functions of histidine decarboxylase and ornithine decarboxylase in injury and repair, andin vitroinvestigations of superoxide dismutase; 4) other causes of mucosal injury, such as indomethacin ulcerations, a duodenal ulcer model, and endotoxemia; and 5) diagnosis of clinical ischemia by novel approaches, including phosphorous spectroscopy, serum creatine kinase isoenzyme assay, and tonometric mucosal pH determinations. The broad subject range touched on by this review reflects the vitality of recent mesenteric circulatory research.