T-Lymphoid Extramedullary (Lymphadenopathic) Blast Crisis In Cml.
作者:
Van DorpeJ.,
Van DammeS.,
JacobsV.,
Van Den BergheH.,
CrielA.,
MichielssenP.,
LouwagieA.,
期刊:
Acta Clinica Belgica
(Taylor Available online 1995)
卷期:
Volume 50,
issue 2
页码: 121-125
ISSN:1784-3286
年代: 1995
DOI:10.1080/17843286.1995.11718433
出版商: Taylor&Francis
数据来源: Taylor
摘要:
SummaryT-cells are only rarely involved in chronic myeloid leukemia. We report an unusual case of T-lymphoid extramedullary (lymphadenopaihic) blast crisis in a 66-year-old patient with Philadelphia positive chronic myeloid leukemia. The lymph node morphological picture resembled that of a peripheral T-cell lymphoma. Immunohistochemical stainings showed most lymph node blasts to have T-phenotype (positivity for CD-2, CD-3 and CD-5). Row cytometric phenotyping confirmed T-phenotype, with positivity for CD-7, CD-38 and TdT. Cytogenetic analysis of lymph node cells revealed Philadelphia chromosome with an additional chromosomal abnormality (add(6p)). The BCR-gene rearrangement in the lymph node blasts was identical to that in the bone marrow. This case adds to the growing evidence that CML may be a disorder of the common stem cell from which T-, Band myeloid progenitors originate.
点击下载:
PDF (3486KB)
返 回