The search for correlation between electrokinetic phenomena and blood thrombus formation on implant materials
作者:
H. L. Milligan,
J. Davis,
K. W. Edmark,
期刊:
Journal of Biomedical Materials Research
(WILEY Available online 1968)
卷期:
Volume 2,
issue 1
页码: 51-79
ISSN:0021-9304
年代: 1968
DOI:10.1002/jbm.820020105
出版商: John Wiley&Sons, Inc.
数据来源: WILEY
摘要:
AbstractBioelectric charge transfer at the blood–wall interface may be a crucial factor affecting thrombosis on implant materials. A program of studies was conducted to determine the electrokinetic and other physical properties of a wide spectrum of materials including organic polymers, metals, inorganics, heterogeneous compounds, and animal tissue. From these tests, materials were selected forin‐vivocannulation experiments. In this manner, a search was made to find a correlation between surface charge characteristics and thrombosis on cardiovascular implant materials. It was found that materials exhibiting a substantial positive charge were prone to rapid thrombosis. No clear correlation can be stated, as yet, regarding the thrombogenecity of highly charged negative surfaces or slightly charged surfaces. However, many heterogeneous materials have exhibited prolongedin‐vivopatency. It appears necessary to isolate surface effects from volumetric effects to seek the role of bioelectric charge transfer in blood thrombus form
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