TRACHEOBRONCHIAL CYTOLOGIC CHANGES AND ABNORMAL SERUM HEME PIGMENTS IN HEMORRHAGIC SHOCK
作者:
ZMIRA FRIEDMAN-MOR,
JACK CHALON,
HERMAN TURNDORF,
LOUIS ORKIN,
期刊:
The Journal of Trauma: Injury, Infection, and Critical Care
(OVID Available online 1977)
卷期:
Volume 17,
issue 11
页码: 829-836
ISSN:0022-5282
年代: 1977
出版商: OVID
数据来源: OVID
摘要:
Significantly elevated numbers of iron laden histiocytes have been shown to appear in the tracheobronchial secretions of subjects in hemorrhagic shock and in patients undergoing open heart-surgery during cardiopulmonary bypass (3, 4). Abnormal heme pigments have also been demonstrated in the serum of dogs bled to hemorrhagic shock (6) and have been felt to be toxic. Because the ingestion of abnormal heme pigments by histiocytes may be part of a defense mechanism, we have attempted to correlate the percentage of iron laden histiocytes found in the tracheobronchial secretions of patients in hemorrhagic shock (Prussian blue method) with the presence of degradation of products of hemoglobin found in their serum by scanning spectrophotometry. There were, generally speaking, few iron laden histiocytes when hemoglobin degradation was advanced, and always numerous iron laden histiocytes when abnormal heme pigments were absent or spectrophotometric findings revealed minor degrees of degradation. Our findings probably reflect the process in the reticuloendothelial systems which eliminates toxic products accumulating in the circulation in low-flow states.
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