Reduction of Nerves Containing Vasoactive Intestinal Polypeptide and Serotonin, but Not Neuropeptide Y and Catecholamine, in Cerebral Blood Vessels of the 8-Week Streptozotocin-Induced Diabetic Rat
作者:
M.L.J. Lagnado,
R. Crowe,
J. Lincoln,
G. Burnstock,
期刊:
Journal of Vascular Research
(Karger Available online 1987)
卷期:
Volume 24,
issue 4
页码: 169-180
ISSN:1018-1172
年代: 1987
DOI:10.1159/000158693
出版商: S. Karger AG
关键词: Cerebral blood vessels;Peptides;Amines;Streptozotocin;Diabetes
数据来源: Karger
摘要:
The perivascular autonomic nerves of the major blood vessels on the ventral surface of the brain were studied in the streptozotocin-induced diabetic rat, an animal model for juvenile onset of diabetes. Histochemical and immunohistochemical techniques were used to determine the pattern and density of perivascular nerves containing catecholamine, 5-hydroxytryptamine (5-HT), vasoactive intestinal polypeptide (VIP) and neuropeptide Y (NPY). A significant reduction in the density and/or fluorescence intensity of 5-HT-immunoreactive nerves was observed in the circle of Willis and its main arterial branches namely: basilar, superior cerebellar, internal carotid, posterior communicating, middle cerebral and anterior cerebral arteries, while a significant reduction of VIP-immunoreactive nerves was observed in the internal carotid, middle cerebral and anterior cerebral arteries, but not in the basilar, superior cerebellar and posterior communicating arteries 8 weeks after the onset of diabetes. However, no changes were observed in the density of NPY- and catecholamine-containing nerves. The results are discussed in relation to autonomic neuropathy of the cerebral blood vessels in diabetes.
点击下载:
PDF
(1625KB)
返 回