Immunohistological Evaluation of Endothelial Markers and Basement Membrane Components in Port-Wine Stains
作者:
Y. Mitsuhashi,
B.F. Odermatt,
B.V. Schneider,
U.W. Schnyder,
期刊:
Dermatology
(Karger Available online 1988)
卷期:
Volume 176,
issue 5
页码: 243-250
ISSN:1018-8665
年代: 1988
DOI:10.1159/000248712
出版商: S. Karger AG
关键词: Immunohistology;Port-wine stain;Endothelial cell;Basement membrane
数据来源: Karger
摘要:
As shown by an immunohistological study, the endothelial cells in the lesions of port-wine stains (PWSs), investigated for factor VΠI-related antigen and Ulex europaeus agglutinin I lectin, were found to be swollen or flattened corresponding to mild or pronounced dilatation of vessels, respectively. Furthermore, dilated vessels in the lesional skin exhibited a broader staining for type IV collagen, laminin and fibronectin, which, however, was not considered to be of primary pathogenetic importance for vessel dilatation in PWSs. As concluded from the number of vessels, no vascular proliferation occurred, which indicates that PWS is not a true hemangioma but a special clinical type of telangiectasia
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