Clinical features and response to treatment of infradiaphragmatic Hodgkin's disease
作者:
Neus Villamor,
Joan C. Reverter,
Josep M. Martí,
Emili Montserrat,
Ciril Rozman,
期刊:
European Journal of Haematology
(WILEY Available online 1991)
卷期:
Volume 46,
issue 1
页码: 38-41
ISSN:0902-4441
年代: 1991
DOI:10.1111/j.1600-0609.1991.tb00511.x
出版商: Blackwell Publishing Ltd
关键词: Hodgkin's disease;infradiaphragmatic presentation;prognosis
数据来源: WILEY
摘要:
Abstract:Among 247 patients with Hodgkin's disease, initial disease presentation was restricted to infradiaphragmatic sites in 17 (6.9%). Advanced age, B symptoms, increased ESR, low lymphocyte and platelet counts, as well as advanced pathological stage and lymphocyte depletion histology were common presenting features of these patients. 7 patients with infradiaphragmatic disease had isolated involvement of inguinofemoral nodes (“peripheral” group) and 10 had only intrabdominal disease (“central” group). Clinical characteristics of patients with “central” forms were different from those with supradiaphragmatic disease, but no differences were observed between “peripheral” infradiaphragmatic and supradiaphragmatic groups. Complete remission was achieved in the 82.2% of patients with infradiaphragmatic disease. Overall survival was 68% at 5 years, and disease‐free survival was 74%. No statistically significant differences were observed in complete remission rates, survival, and disease‐free survival when supradiaphragmatic, “central” infradiaphragmatic and “peripheral” infradiaphr
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