Randomized Trial for the Control of Acute Vomiting in Cisplatin-Treated Patients: High-Dose Metoclopramide with Dexamethasone and Lorazepam as Adjuncts versus High-Dose Alizapride plus Dexamethasone and Lorazepam
作者:
I. Moreno,
R. Rosell,
A. Abad-Esteve,
A. Barnadas,
J. Carles,
N. Ribelles,
期刊:
Oncology
(Karger Available online 1991)
卷期:
Volume 48,
issue 5
页码: 397-402
ISSN:0030-2414
年代: 1991
DOI:10.1159/000226967
出版商: S. Karger AG
关键词: Alizapride;Acute emesis;Cisplatin-based chemotherapy;Delayed emesis;Metoclopramide;Side effects
数据来源: Karger
摘要:
This study investigated the antiemetic activity of two different acute antiemesis regimens in patients receiving cisplatin-based chemotherapy. Seventy-four patients were treated with high-dose metoclopramide, dexamethasone and lorazepam (MDL) and 71 patients received high-dose alizapride, dexamethasone and lorazepam (ADL). Complete protection from vomiting was 50% in MDL-treated patients as compared with 30% in the ADL arm (p = 0.04). Incidence of delayed emesis was assessed in the first 82 patients accrued for the 120 h postcisplatin, being 69 and 60% in MDL and ADL, respectively.
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