Characteristics of the Receptors Which Mediate the Stimulation of ACTH Secretion by Vasopressin in Conscious Dogs
作者:
Jeffrey Schwartz,
Ian A. Reid,
期刊:
Neuroendocrinology
(Karger Available online 1986)
卷期:
Volume 42,
issue 2
页码: 93-96
ISSN:0028-3835
年代: 1986
DOI:10.1159/000124256
出版商: S. Karger AG
关键词: Vasopressin;Adrenocorticotropic hormone;Corticosteroids;Antidiuretic receptors;Vasoconstrictor receptors;Vasopressin analogs;Conscious dogs
数据来源: Karger
摘要:
In order to characterize the receptors which mediate the adrenocorticotropic hormone (ACTH) response to vasopressin in conscious animals, plasma 11-hydroxycorticosteroid concentration was measured in conscious dogs during the infusion of vasopressin or structural analogs of vasopressin which exhibit selective antidiuretic or vasoconstrictor activity. Vasopressin (1.0 ng/kg/min for 60 min) increased mean arterial pressure, decreased heart rate and increased plasma corticosteroid concentration from 1.0 ± 0.2 to 2.2 ± 0.2 µg/dl (p < 0.001). A specific antagonist of the vasoconstrictor activity of vasopressin, d(CH2)5MeTyrAVP (10 µg/kg), completely blocked the cardiovascular and corticosteroid responses to vasopressin. A selective vasoconstrictor (V1) agonist, PheOrnOT (1.0 ng/kg/min), which produced the same cardiovascular responses as vasopressin, increased plasma corticosteroid concentration from 1.1+0.1 to 2.9 ±0.9 µg/dl (p < 0.005). In marked contrast, a selective antidiuretic (V1) agonist, dDAVP (1.0 ng/kg/min) had no effect on blood pressure, heart rate or plasma corticosteroid concentration. These results indicate that the stimulation of ACTH release by vasopressin in conscious dogs is mediated by receptors which resemble vasoconstrictor-type (V1) receptors rather than antidiuretic-type (V<) rece
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