Properties of inbred strains and outbred stocks, with special reference to toxicity testing
作者:
MichaelF. W. Festing,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1979)
卷期:
Volume 5,
issue 1
页码: 53-68
ISSN:0098-4108
年代: 1979
DOI:10.1080/15287397909529725
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Genetically uniform or isogenic strains (inbred strains and F1hybrids) have a number of properties that make them valuable in toxicity testing, provided the experimental design can be modified to include more than one such strain. Isogenicity and homozygosity lead to great phenotypic uniformity, high long‐term genetic stability, high identifiability, large differences between strains (individuality), and the possibility of setting up daughter colonies genetically identical to the parents. This in turn means that many isogenic strains are internationally distributed, and that considerable background data exist on the characteristics of the common strains.
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