Function of the Isolated Spontaneously Hypertensive Rat Kidney after Blood Pressure Reduction
作者:
Thomas H. Steele,
Jeanne H. Gottstein,
Laura Challoner-Hue,
期刊:
Kidney and Blood Pressure Research
(Karger Available online 1985)
卷期:
Volume 8,
issue 2
页码: 65-72
ISSN:1420-4096
年代: 1985
DOI:10.1159/000173037
出版商: S. Karger AG
关键词: Spontaneously hypertensive rat;Antihypertensive treatment;Isolated perfused SHR kidney;Vasodilators;Hydralazine;Diazoxide
数据来源: Karger
摘要:
We treated 20-week-old spontaneously hypertensive rats (SHR) with either placebo or hydralazine, reserpine and hydrochlorothiazide for 1 month. Mean arterial pressure in treated SHR averaged 113 ± 7 mm Hg (mean ± SE), compared to 162 ± 12 mm Hg in animals receiving placebo (p < 0.01). Glomerular filtration rate (GFR) and sodium excretion were similar in both groups. In isolated perfused kidneys, the GFR and sodium excretion were significantly greater in the treatment group than in the placebo group at a perfusion pressure of 140 mm Hg (p < 0.01). Renal vascular resistance (RVR) of kidney from treated SHR was no different from RVR of kidney from placebo SHR. Hydralazine (6 mM) and diazoxide (4 mM) increased the GFR and sodium excretion of isolated SHR kidney perfused at 140 mm Hg (p < 0.05), but decreased RVR significantly (p < 0.05). We conclude that prolonged antihypertensive treatment renders higher GFR values to isolated SHR kidneys perfused at 140 mm Hg, with sodium excretion varying in proportion to the GFR. The addition of vasodilators to the perfusate of isolated SHR kidneys partially reproduced these changes, but only at extremely high concentrations unlike to be attained in vi
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