Endocrine Control of Appetite: Gastrointestinal Hormonal Effects on CNS Appetitive Structures
作者:
M.C. Schanzer,
E.D. Jacobson,
N. Dafny,
期刊:
Neuroendocrinology
(Karger Available online 1978)
卷期:
Volume 25,
issue 6
页码: 329-342
ISSN:0028-3835
年代: 1978
DOI:10.1159/000122754
出版商: S. Karger AG
关键词: Cholecystokinin;Evoked potentials;Unanesthetized rats;Hypothalamus;Appetite;Neurohumoral feedback mechanism
数据来源: Karger
摘要:
Permanent semi-microelectrodes were implanted in the ventromedial hypothalamus (VMH), lateral hypothalamus (LH), amygdala (AMYG), medial forebrain bundle (MFB), anterior hypothalamus (AH), inferior colliculus (IC), and caudate nucleus (CN). Average evoked responses were recorded simultaneously from the above sites in freely behaving rats before and after administration of pentagastrin (100 μg/kg), secretin 1 μg/kg or cholecystokinin octapeptide (CCK-OP) (1 μg/kg) in search of satiety signal. Gastrin and secretin had little effect while it appears that CCK may perform a regulatory function in a neurohumoral feedback mechani
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